Scientists at Texas A&M identify method that enables mammal tissue regeneration

Researchers at Texas A&M University’s College of Veterinary Medicine and Biomedical Sciences have identified a two-step experimental approach that may help trigger regenerative responses in mammals, according to a study published in Nature Communications.

The work challenges long-standing assumptions about mammalian healing, where injury typically leads to scar formation rather than tissue regrowth. Instead, the team found that key healing cells, known as fibroblasts, may be redirected under specific conditions to support regeneration.

The approach begins after an injury has already closed. In the first stage, the researchers applied fibroblast growth factor 2 (FGF2), which encouraged cells at the wound site to form a blastema-like structure. This structure is associated with regeneration in species such as salamanders, but does not normally appear in mammals.

Several days later, a second growth factor, bone morphogenetic protein 2 (BMP2), was introduced. This signal prompted the cells to begin forming new tissue structures, including bone, tendon, ligament and joint components.

While the treatment led to the regeneration of major tissue types, the structures did not fully replicate the original anatomical form. Researchers emphasised that the outcome represents partial but meaningful biological reconstruction rather than complete replacement.

The study also suggests that regeneration may not require external stem cell transplantation. Instead, existing cells within the injury environment appear capable of shifting behaviour when exposed to the correct sequence of signals.

Evidence of positional re-specification was also observed, indicating that cells can adopt new developmental roles during repair, rather than remaining fixed to their original function.

Although the findings remain experimental, the researchers say the method could eventually contribute to improved wound healing and reduced scarring. BMP2 already has FDA-approved medical applications, while FGF2 is under investigation in clinical trials, which may support future translation.

The authors conclude that regenerative potential in mammals may not be absent, but instead biologically suppressed under normal healing conditions, and could be reactivated under controlled circumstances.

What role should regenerative medicine play in future healthcare? Share your thoughts as research into tissue repair continues to advance. Explore more science and medical research coverage at EyeOnLondon.

Follow us on:

Subscribe to our YouTube channel for the latest videos and updates!

We value your thoughts! Share your feedback and help us make EyeOnLondon even better!